Inhibition of Phytohemagglutinin-Induced In Vitro Lymphocyte Transformation by Serum From Patients With Carcinoma
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Auteurs : W. Frederick Sample [États-Unis] ; Harold R. Gertner [États-Unis] ; Paul B. Chretien [États-Unis]Source :
- Journal of the National Cancer Institute [ 0027-8874 ] ; 1971.
Abstract
The in vitro reactivity in autologous serum of lymphocytes from 100 normal persons and 120 cancer patients was determined by quantitation of phytohemagglutinin-induced tritiated thymidine incorporation. With the data from the study of normal lymphocytes, an age-correlated range of normal lymphocyte reactivity in autologous serum was derived. With this used as the criterion, the sera of 9 patients with carcinoma, whose lymphocytes in autologous serum had markedly low reactivity, were isolated and assayed for a suppressive effect on normal lymphocyte reactivity. A pool of AB sera, in which the reactivity of normal lymphocytes did not differ from their reactivity in autologous serum, was used as a constant homologous reference serum. The reactivity of normal lymphocytes in serum from each of the 9 cancer patients was lower than their reactivity in the homologous pooled AB serum. The data demonstrate an inhibitor of normal lymphocyte reactivity in the sera of patients with carcinoma.
Url:
DOI: 10.1093/jnci/46.6.1291
Affiliations:
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Frederick" last="Sample">W. Frederick Sample</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Surgery Branch, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Gertner, Harold R" sort="Gertner, Harold R" uniqKey="Gertner H" first="Harold R." last="Gertner">Harold R. Gertner</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Surgery Branch, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Chretien, Paul B" sort="Chretien, Paul B" uniqKey="Chretien P" first="Paul B." last="Chretien">Paul B. Chretien</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Surgery Branch, National Cancer Institute, Bethesda</wicri:cityArea></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of the National Cancer Institute</title><title level="j" type="abbrev">Journal of the National Cancer Institute</title><idno type="ISSN">0027-8874</idno><idno type="eISSN">1460-2105</idno><imprint><publisher>Oxford University Press</publisher><date when="1971-06">1971</date><biblScope unit="vol">46</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1291">1291</biblScope><biblScope unit="page" to="1297">1297</biblScope></imprint><idno type="ISSN">0027-8874</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0027-8874</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The in vitro reactivity in autologous serum of lymphocytes from 100 normal persons and 120 cancer patients was determined by quantitation of phytohemagglutinin-induced tritiated thymidine incorporation. With the data from the study of normal lymphocytes, an age-correlated range of normal lymphocyte reactivity in autologous serum was derived. With this used as the criterion, the sera of 9 patients with carcinoma, whose lymphocytes in autologous serum had markedly low reactivity, were isolated and assayed for a suppressive effect on normal lymphocyte reactivity. A pool of AB sera, in which the reactivity of normal lymphocytes did not differ from their reactivity in autologous serum, was used as a constant homologous reference serum. The reactivity of normal lymphocytes in serum from each of the 9 cancer patients was lower than their reactivity in the homologous pooled AB serum. The data demonstrate an inhibitor of normal lymphocyte reactivity in the sera of patients with carcinoma.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Sample, W Frederick" sort="Sample, W Frederick" uniqKey="Sample W" first="W. Frederick" last="Sample">W. Frederick Sample</name></region><name sortKey="Chretien, Paul B" sort="Chretien, Paul B" uniqKey="Chretien P" first="Paul B." last="Chretien">Paul B. Chretien</name><name sortKey="Gertner, Harold R" sort="Gertner, Harold R" uniqKey="Gertner H" first="Harold R." last="Gertner">Harold R. Gertner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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